MAC can be seen with which systemic condition?

MAC can be seen with which systemic condition?

• A. Severe chronic hyperparathyroidism
• B. Renal failure
• C. Hypertension
• D. Diabetes

Answer: (A)

Mitral annular calcification reflects calcium-phosphate–related calcification in the fibrous ring of the mitral valve. Severe chronic hyperparathyroidism drives high calcium levels (and often higher calcium-phosphate product), promoting deposition of calcium on the mitral annulus. This makes MAC a common finding in patients with significant hyperparathyroidism. While renal failure can contribute to MAC indirectly through secondary hyperparathyroidism, the direct systemic abnormality most tightly linked to MAC in this context is hyperparathyroidism. Hypertension and diabetes are common comorbidities but are not as specifically causative for MAC.

Mitral annular calcification reflects calcium-phosphate–related calcification in the fibrous ring of the mitral valve. Severe chronic hyperparathyroidism drives high calcium levels (and often higher calcium-phosphate product), promoting deposition of calcium on the mitral annulus. This makes MAC a common finding in patients with significant hyperparathyroidism. While renal failure can contribute to MAC indirectly through secondary hyperparathyroidism, the direct systemic abnormality most tightly linked to MAC in this context is hyperparathyroidism. Hypertension and diabetes are common comorbidities but are not as specifically causative for MAC.